Document registry — page 27
Every document the Institute has published, 1,639 in total, with its identifier, type, certainty rating and review date.
Documents
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Growth-hormone-releasing hormone analogue. Tesamorelin stimulates the pituitary to release endogenous growth hormone in a pulsatile pattern, preserving the physiological feedback architecture…
Moderate01 Sep 2024 -
Randomised, double-blind, placebo-controlled study of Gonadorelin in gh axis over as stated in the parent protocol. The Institute holds no reported primary result for…
Very low31 Aug 2024 -
Peptides, SARMs, injectable oils and raw materials.
28 Aug 2024 -
Consultation on the draft monograph for Hexarelin, which the assessment committee released for public comment before ratification. The draft grades the compound's…
27 Aug 2024 -
GLP-1 receptor agonist (acylated, once-daily). Receptor pharmacology is that of the selective GLP-1 class. The pharmacokinetic engineering differs: self-association into heptamers at the…
High27 Aug 2024 -
What is the evidence that glucagon-like peptide-1 receptor agonism increases the risk of medullary thyroid carcinoma in humans?
Low23 Aug 2024 -
Acute or overuse injury of tendon, ligament or muscle, with healing assessed by imaging, function and return-to-activity endpoints.
21 Aug 2024 -
Phase 1 ascending dose, phase 1 study of Survodutide in mash over as stated in the parent protocol. The Institute holds no reported primary result for this record and…
Very low20 Aug 2024 -
Related-substances profiling and the detection of isobaric impurities
High19 Aug 2024 -
Observational, phase 1 study of Petrelintide in obesity over as stated in the parent protocol. The Institute holds no reported primary result for this record and…
Very low18 Aug 2024 -
GLP-1 receptor agonist (acylated, long-acting). Semaglutide is a full agonist at the glucagon-like peptide-1 receptor, a class B G protein-coupled receptor signalling principally through Gαs and…
High16 Aug 2024 -
Melanocortin receptor agonist (cyclic heptapeptide). Bremelanotide activates central melanocortin-4 receptors, acting on hypothalamic and limbic circuits regulating sexual desire. Unlike…
Moderate15 Aug 2024 -
Unimolecular amylin and GLP-1 receptor co-agonist. A single peptide engineered to activate both the amylin and GLP-1 receptor systems, combining two complementary satiation mechanisms without the…
Low11 Aug 2024 -
Consultation on the draft monograph for Kisspeptin-10, which the assessment committee released for public comment before ratification. The draft grades the compound's…
10 Aug 2024 -
Phase 1 ascending dose, phase 1 study of Cagrilintide in obesity over up to 12 weeks. The Institute holds no reported primary result for this record and publishes no…
Very low09 Aug 2024 -
Randomised crossover, phase 1 study of Selank in cognition over as stated in the parent protocol. The Institute holds no reported primary result for this record and…
Very low06 Aug 2024 -
Randomised, double-blind, placebo-controlled study of Semax in cognition over as stated in the parent protocol. The Institute holds no reported primary result for this…
Very low05 Aug 2024 -
Consultation on the second version of the framework the Institute uses to rate certainty in a body of evidence. The revision retains the four-level GRADE scale and…
04 Aug 2024 -
Phase 1 ascending dose, phase 1 study of Petrelintide in obesity over as stated in the parent protocol. The Institute holds no reported primary result for this record…
Very low01 Aug 2024 -
Randomised, double-blind, placebo-controlled, phase 3 study of Tirzepatide in sleep apnoea and obesity over as stated in the parent protocol. The Institute holds no…
Very low26 Jul 2024 -
Phase 1 ascending dose, phase 1 study of Tirzepatide in obesity over as stated in the parent protocol. The Institute holds no reported primary result for this record and…
Very low18 Jul 2024 -
Phase 1 ascending dose, phase 1 study of Gonadorelin in gh axis over as stated in the parent protocol. The Institute holds no reported primary result for this record and…
Very low17 Jul 2024 -
Single-arm open-label study of Semax in cognition over open-label extension of the parent trial. The Institute holds no reported primary result for this record and…
Very low16 Jul 2024 -
Randomised, double-blind, placebo-controlled, phase 3 study of Semaglutide in hfpef and type 2 diabetes over as stated in the parent protocol. The Institute holds no…
Very low15 Jul 2024 -
Growth-hormone-releasing hormone analogue with albumin-binding drug affinity complex. Both variants are GHRH receptor agonists that increase pulsatile growth-hormone secretion and, downstream, IGF-1. The DAC variant…
Low14 Jul 2024 -
Protocol for independent third-party verification of a supplied preparation
High12 Jul 2024 -
Single-arm open-label study of Gonadorelin in gh axis over months. Primary result: Effective when delivered by pump at a physiological pulse frequency. Non-pulsatile…
Moderate12 Jul 2024 -
Consultation on the policy governing the public register of Institute members, reviewers, correspondents and contributors: who appears, what is published about each, and…
10 Jul 2024 -
Chronic immune-mediated inflammation of the intestinal tract, or disorders of intestinal permeability including coeliac disease.
08 Jul 2024 -
Consultation on the draft monograph for IGF-1 LR3, which the assessment committee released for public comment before ratification. The draft grades the compound's…
07 Jul 2024 -
Consultation on the draft monograph for LL-37, which the assessment committee released for public comment before ratification. The draft grades the compound's principal…
05 Jul 2024 -
GLP-1 receptor agonist, oral formulation with absorption enhancer. Receptor pharmacology is identical to subcutaneous semaglutide. The distinguishing pharmacology is absorption: SNAC buffers the gastric…
High28 Jun 2024 -
Consultation on the draft of CEI-MS-15, which specifies the performance a determination must achieve for documentation and states what the resulting figure does not…
27 Jun 2024 -
Randomised crossover, phase 1 study of Gonadorelin in gh axis over as stated in the parent protocol. The Institute holds no reported primary result for this record and…
Very low26 Jun 2024 -
Consultation on the draft of CEI-MS-03, which specifies the performance a determination must achieve for content and states what the resulting figure does not establish…
24 Jun 2024 -
Record of documents ratified in the 2024 Q2 assessment cycle.
22 Jun 2024 -
Consultation on the draft monograph for Petrelintide, which the assessment committee released for public comment before ratification. The draft grades the compound's…
20 Jun 2024 -
Randomised, double-blind, placebo-controlled, phase 3 study of Maridebart cafraglutide in type 2 diabetes over as stated in the parent protocol. The Institute holds no…
Very low20 Jun 2024 -
Consultation on the draft of this intervention review, which registers the question: Does the cardiovascular effect of a glucagon-like peptide-1 receptor agonist…
19 Jun 2024 -
Recombinant insulin-like growth factor 1 analogue. IGF-1 receptor agonism with greatly reduced binding-protein sequestration. The consequence is a sustained, unbuffered IGF-1 receptor signal. Because…
Very low18 Jun 2024
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