Biological ageing and healthspan endpoints — compounds assessed
The 9 compounds the Institute assesses in biological ageing and healthspan endpoints.
§4Compounds assessed
Compounds the Institute assesses in this indication, with the class of each and its overall certainty. A compound appears here whether or not the evidence supports its use, because recording that a compound has been studied and found wanting is as much part of the assessment as recording that one has not.
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Russian observational and small controlled reports describe mortality and functional differences over multi-year follow-up — The Institute assesses these reports as not permitting a certainty rating above very low. It records that mortality claims of this…
Very low -
No human trial identified — —
Not rated -
Growth-hormone-releasing hormone analogue with albumin-binding drug affinity complex0 contributing trialsfull monograph
No randomised human evidence identified — No trial supports any ageing or healthspan claim.
Not rated -
No randomised human evidence for any systemic ageing endpoint — The declining-with-age plasma concentration is an observation, not evidence of an intervention effect.
Not rated -
No randomised evidence for any ageing endpoint — —
Not rated -
No randomised controlled human trial identified — Observational associations between endogenous MOTS-c concentration and metabolic phenotype exist; these are associations, not intervention evidence.
Not rated -
No randomised controlled human trial of administered NAD+ on any ageing endpoint identified — Trials of the oral precursors nicotinamide riboside and nicotinamide mononucleotide exist and report raised blood NAD+ concentrations with limited functional effect…
Not rated -
No randomised human evidence identified — Marketing claims in this indication are not supported by any trial the Institute has been able to locate.
Not rated -
No assessable evidence identified — —
Not rated
References cited on this page
References are numbered in order of first citation in this document. Each superscript in the text links to its entry below.
- Khavinson VK, Kuznik BI, Tarnovskaya SI, Linkova NS. Peptides and CCL11 and HMGB1 as differently expressed age-dependent proinflammatory biomarkers of ageing. Advances in Gerontology 2020;10(1):1–8. identifier not held by the Institute The digital object identifier previously carried on this record did not resolve and has been withdrawn. Journal and year are retained.
Identifiers are reproduced only where the Institute holds them. Where a digital object identifier or PubMed identifier is not shown, the Institute has recorded the journal and year and has not constructed an identifier.