Draft synthesis: Weight-reducing agents for obstructive sleep… — disposition

§3Disposition and amendments

§3.1Disposition table

Table 1. Every submission with its disposition. Each row links to the submission in full.

§3.2Summary by disposition

Table 2. Counts by disposition, with the meaning of each.

§3.3Resulting amendments

1. The timepoint at which each outcome was extracted was chosen after the data were seen — arising from DRAFT-SLEEP-APNOEA/001. The extraction timepoint is now prespecified in the protocol for new reviews. Where a review predates the requirement, estimates are reported at every timepoint the contributing trials report.
2. Point estimates are given without an interval — arising from DRAFT-SLEEP-APNOEA/002. Every estimate now carries its interval where the source reported one, and where it did not, the estimate is annotated as reported without an interval rather than left to appear as a precise figure.
3. Results at materially different follow-up durations are pooled — arising from DRAFT-SLEEP-APNOEA/003. Estimates are now reported by duration band, with the number of contributing trials and participants in each band stated, and no estimate is pooled across bands.
4. Doses differing several-fold are pooled without examining dose-response — arising from DRAFT-SLEEP-APNOEA/004. Estimates are now reported by dose group, a dose-response examination is reported where three or more dose levels contribute, and the pooled across-dose estimate is removed rather than retained alongside.
5. Studies using different outcome definitions are pooled into one estimate — arising from DRAFT-SLEEP-APNOEA/005. Studies are now pooled only within an outcome definition, each definition is reported with its own estimate and certainty rating, and the summary of findings states which definition each row concerns.
6. The search was limited by publication date and the limit is not justified — arising from DRAFT-SLEEP-APNOEA/006. Every date limit in the series now carries its justification in the search-strategy section. Limits that could not be justified on re-examination have been removed and the affected searches re-run.
7. The axis of the forest plot exaggerates a small difference — arising from DRAFT-SLEEP-APNOEA/007. Forest plots now carry a marked minimally important difference wherever a published one exists for the outcome, with its source cited. Where none exists the figure says so beneath the axis.
8. An indirect comparison is presented without an assessment of transitivity — arising from DRAFT-SLEEP-APNOEA/008. Transitivity is now assessed against a stated list of effect modifiers and reported before any indirect estimate, and where the assessment fails the contrast is reported as unestimable with the reason rather than estimated with a caveat.
9. The comparator was given at a dose below the one in general use — arising from DRAFT-SLEEP-APNOEA/009. Comparator dose is now a column in the included-studies table, and a sensitivity analysis restricted to comparators at the dose in general use is reported wherever the trials permit it.
10. One trial appears to be included twice under two publications — arising from DRAFT-SLEEP-APNOEA/010. Included studies are now recorded against a trial identifier, with publications listed beneath it, and the included-studies table reports the number of trials and the number of reports separately.
11. Risk-of-bias judgements are reported as an overall rating without the domains — arising from DRAFT-SLEEP-APNOEA/011. Risk of bias is now reported at domain level for every included study, with the text on which each judgement was based quoted and referenced, and the overall judgement derived from the domains rather than asserted alongside them.
12. References should carry a persistent identifier for every cited source — arising from DRAFT-SLEEP-APNOEA/012. Every reference without a persistent identifier now carries an explicit statement that the identifier is not held by the Institute, so that its absence is a recorded fact rather than an apparent oversight.
13. The search strategy as published cannot be re-run — arising from DRAFT-SLEEP-APNOEA/014. The full line-by-line strategy for each database is now published with the interface, the run date and the yield at each line, and the total retrieved is reconciled against the screening flow.
14. Registered trials that never reported are not counted anywhere in the review — arising from DRAFT-SLEEP-APNOEA/016. Registered trials without posted results are now identified, counted and reported as a distinct category in the screening flow, with the proportion of registered participants they represent stated in the limitations.

References cited on this page

References are numbered in order of first citation in this document. Each superscript in the text links to its entry below.

1. International Organization for Standardization. ISO/IEC 17025:2017 General Requirements for the Competence of Testing and Calibration Laboratories. ISO/IEC Standard 2017;3rd edition. identifier not held by the Institute

Identifiers are reproduced only where the Institute holds them. Where a digital object identifier or PubMed identifier is not shown, the Institute has recorded the journal and year and has not constructed an identifier.