Draft synthesis: Cardiovascular outcomes with glucagon-like… — disposition

§3Disposition and amendments

§3.1Disposition table

Table 1. Every submission with its disposition. Each row links to the submission in full.

§3.2Summary by disposition

Table 2. Counts by disposition, with the meaning of each.

§3.3Resulting amendments

1. Regulatory assessment documents were not searched — arising from DRAFT-INCRETIN-CAR/001. Published regulatory assessment documents are now searched as a named source, are reported as a distinct evidence class in the included-studies table, and contribute to the assessment while being excluded from pooled estimates where risk of bias could not be…
2. Results at materially different follow-up durations are pooled — arising from DRAFT-INCRETIN-CAR/002. Estimates are now reported by duration band, with the number of contributing trials and participants in each band stated, and no estimate is pooled across bands.
3. Point estimates are given without an interval — arising from DRAFT-INCRETIN-CAR/003. Every estimate now carries its interval where the source reported one, and where it did not, the estimate is annotated as reported without an interval rather than left to appear as a precise figure.
4. Studies not published in English were excluded without assessment — arising from DRAFT-INCRETIN-CAR/004. Language restriction is removed from the protocol for the series, the records previously excluded on that ground are listed with their screening outcome, and the residual limitation is stated in the abstract of this review.
5. A surrogate outcome is used as the anchor without validation evidence — arising from DRAFT-INCRETIN-CAR/006. Where the anchor is a surrogate, the synthesis now states the evidence for the surrogate relationship, rates it separately, and downgrades the anchor rating for indirectness accordingly rather than carrying the surrogate as though it were the outcome of…
6. Studies using different outcome definitions are pooled into one estimate — arising from DRAFT-INCRETIN-CAR/008. Studies are now pooled only within an outcome definition, each definition is reported with its own estimate and certainty rating, and the summary of findings states which definition each row concerns.
7. Efficacy outcomes are rated for certainty and harms are not — arising from DRAFT-INCRETIN-CAR/009. Every reported harm now carries a certainty rating on the same scale as the efficacy outcomes, with the downgrade reasons stated, and discontinuation for adverse events appears in the summary of findings rather than in an annex.
8. Analytical surveys are treated as evidence about suppliers when they establish only what was in a… — arising from DRAFT-INCRETIN-CAR/010. Provenance is now assessed for every included survey and reported as a study characteristic, surveys without establishable provenance are reported separately rather than pooled with those that have it, and no supplier-level inference is drawn from a…
9. Doses differing several-fold are pooled without examining dose-response — arising from DRAFT-INCRETIN-CAR/011. Estimates are now reported by dose group, a dose-response examination is reported where three or more dose levels contribute, and the pooled across-dose estimate is removed rather than retained alongside.
10. Statistical heterogeneity is treated as though it measured clinical heterogeneity — arising from DRAFT-INCRETIN-CAR/012. The decision to pool is now justified in prose against the population, intervention, comparator and outcome before any statistic is presented, and the heterogeneity statistic is reported with its confidence interval and a note of the number of contributing…
11. The timepoint at which each outcome was extracted was chosen after the data were seen — arising from DRAFT-INCRETIN-CAR/013. The extraction timepoint is now prespecified in the protocol for new reviews. Where a review predates the requirement, estimates are reported at every timepoint the contributing trials report.

References cited on this page

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1. International Organization for Standardization. ISO/IEC 17025:2017 General Requirements for the Competence of Testing and Calibration Laboratories. ISO/IEC Standard 2017;3rd edition. identifier not held by the Institute

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